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Vitamin C reconfigures the gut microbiota, improves the intestinal environment, reduces inflammatory responses and oxidative stress in the paraventricular nucleus of the hypothalamus, thereby weakening sympathetic nervous activity in hypertensive rats and lowering blood pressure (83)
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IL-1 can activate MAPKp38 and c-Jun by TAK1 to induce COX-2 and produce PGE2
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