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αESA-induced ferroptosis is ACSL1-dependent The first step in esterification of fatty acids into lipids is their conjugation to coenzyme A (CoA), catalyzed by acyl-CoA fatty ligases

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When Atg5 and Atg7 are silenced, a reduction in Fe 2+ levels and a decrease in the production of lipid peroxidation products are observed, which suggests that autophagy mediated by Atg5 and Atg7 is crucial for the induction of ferroptosis [72]