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For example, in European Americans (EA) and Latino Americans (LA), the DRB1*1104, DQA1*0501, DQB1*0301 haplotype, and DQB1 alleles encoding a non-leucine residue at position 26 (DQB1 26 epi) showed the strongest associations with SSc, while the strongest association for African Americans (AA) was with DRB1*0804 and HLA-DRB1*1102
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The latter may be caused by intestinal disorders, infections, bariatric surgery, or pharmacological interference, including histamine H2 receptor antagonists and metformin