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The use of metformin in a regimen with other antihyperglycemic medications, such as sodium-dependent glucose transporters-2 inhibitors, dipeptidyl peptidase-4 inhibitors, glibenclamide, glucagon-like peptide-1 receptor agonists, is more effective than metformin alone in lowering blood glucose levels [41]

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Across contemporary scientific discussions, mucosal delivery variants of AOD-9604 + MOTS-c versus traditional subcutaneous administration methods consistently surface in exploratory framework evaluations regarding direct nose-to-brain transport efficiency, absorption pharmacokinetics, and mucosal barrier tolerance, with researchers actively tracking localized nasal passage irritation, mild mucosal dryness, or variable bioavailability coefficients.