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No Receptor Overlap Retatrutide hits metabolic receptors (GLP-1R, GIPR, GCGR)

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Due to their hemodynamic/antihypertensive, anti-inflammatory/antifibrotic, and angiotensin II receptor blockade actions, ACE inhibitors and angiotensin II receptor blockers are the backbone of pharmaceutical therapy for CKD, attempting to halt the development of ESRD [4]