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Recordings of medium spiny neurons (MSNs), the main striatal projection neuron, from ethanol drinking monkeys show the balance of Glut and gamma-amino-butyric acid (GABA) mediated synaptic transmission is regionally specific, with greater putamen excitatory tone

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Possessing high anti-excitotoxic and anti-inflammatory neuroprotective efficacy, they are able to interfere with calcium influx into cells, stabilize mitochondria, inhibit proteolytic enzymes, induce survival signaling, and reduce oxidative stress [54,55,56,57]