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Even though the demonstration of vitamin B12 deficiency is one of the main aspect for the diagnosis, it has been proved that measuring serum vitamin B12 level alone is not sufficient to diagnose the deficiency and its sensitivity is questionable

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Some studies have shown that zinc is critical for the transcriptional activity of Nrf2 [5], and a meta-analysis reported that zinc supplementation may improve serum CRP levels in patients with renal failure [6]