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Each of those outcomes has a specific research use: body-composition change is the primary endpoint researchers track when evaluating NNMT inhibition, cholesterol and adipocyte-size data support the broader metabolic-health angle of the mechanism, and the unchanged food intake is the detail that lets researchers rule out appetite suppression as the explanation for the weight change

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In the absence of impaired kidney function, an elevated MMA level in conjunction with elevated homocysteine suggests either a vitamin B 12 deficiency or a combined vitamin B 12 and folate deficiency (32)