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HGF itself is able to trigger the transcription of c-Met (Boccaccio et al., 1994), and it is thus HGF, which is universally expressed by stromal cells throughout the body that typically drives tumor over expression of c-Met (Aguirre Ghiso et al., 1999

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[PubMed] [Google Scholar] 65.Anisimov V.N., Khavinson V.K., Mikhalski A.I., Yashin A.I