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Abbreviations MSCs Mesenchymal stem cells TBI Traumatic brain injury ROS Reactive oxygen species EVs Extracellular vesicles TNFa Necrosis Factor alpha IL- 6 Interleukin 6 NLRP Pyrin domain (PYD)-containing protein EVs Extracellular vesicles DAMPs Danger-associated molecular patterns PAMPs Pathogen-related molecular patterns NF-κB Nuclear factor kappa B NLRPs NOD-like receptor protein family ASC Apoptosis-related spot like proteins containing cysteine protease recruitment domains Caspase- 1 Cysteine containing aspartic acid protease 1 IL Interleukin mTORC1 Mechanistic target of rapamycin complex 1 ATG Anti-thymocyte globulins AMPK AMP-activated protein kinase SIRT1 Sirtuin 1 PIK Phosphatidylinositol (PI) kinase miR MicroRNA NF-κB Nuclear factor-kappaB p38 MAPK Mitogen-activated protein kinase LC3-II Microtubule-associated protein 1 light chain 3 Akt Protein kinase B VEGF Vascular endothelial growth factor FGF Fibroblast growth factor Author contributions Conceptualization was conducted by MWL, HL, and LMZ