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One study found that after injecting high doses of vitamin B12 (specifically cyanocobalamin) into rodents, the B12 stayed in the bloodstream for a relatively short period, with a half-life ranging from 20 to 50 minutes

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Most people who follow a healthy diet and consume animal products get enough B12, but some people who follow a vegetarian or vegan diet may not get enough B12 from the foods they eat and might benefit from a vitamin B12 supplement