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A similar architecture, an anionic Arg263 anchor combined with a bulky, lipophilic aromatic framework tailored to the P1-P4 region, is also characteristic of AZD5991 and other newer (often macrocyclic) MCL-1 inhibitors [134]
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For example, CFE has been used to commercially synthesize antibody-drug conjugates that incorporate ncAAs such as p -azidophenylalanine and p -azidomethylphenylalanine 532 that serve as click chemistry handles
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