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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]
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it acts as a roborant in cases of stress, overexertion, exhaustion and reduced resistance, and as a tonic in cases of weakness, secondary anaemia and chilling
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