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Importantly, HSPA1 can be degraded by the UPS, and CHIP blockade prevents this degradation, which is a useful tool for slowing the pace of cell death (e.g., in cardiovascular pathology) ( HSC70 has been recently shown to ensure proper interaction between S-phase kinase-associated protein 1/cullin 1/F-box protein (SCF) and constitutive photomorphogenesis 9 signalosomes (CSNs) (Zeng et al., 2025)

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US20240083873A1 - Pyrimidine carboxamide compound and application thereof - Google Patents Pyrimidine carboxamide compound and application thereof Download PDF Info Publication number US20240083873A1 US20240083873A1 US18/028,213 US202118028213A US2024083873A1 US 20240083873 A1 US20240083873 A1 US 20240083873A1 US 202118028213 A US202118028213 A US 202118028213A US 2024083873 A1 US2024083873 A1 US 2024083873A1 Authority US United States Prior art keywords independently alkyl diseases halogen butyl Prior art date Legal status (The legal status is an assumption and is not a legal conclusion