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In phase 3 trials, after 56 weeks of treatment, 62% of patients receiving contrave 32 (bupropion SR 360 mg/naltrexone SR 32 mg) lost at least 5% of their body weight as compared to 23% of patients in the placebo group [240]

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This increase in NAD⁺ availability improves metabolic flexibility , enabling the body to switch between carbohydrate and fat fuel sources more efficiently