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To investigate whether QMP would secure a long plasma half-life of a GLP-1 albumin fusion, we constructed a recombinant fusion protein with the identical amino acid sequence as Tanzeum (albiglutide-mimic: GLP-1 WT), as well as a modified version containing the QMP substitutions (GLP-1 QMP) (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 427.MacFarlane EG, Haupt J, Dietz HC, Shore EM