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Prompting the hypothesis that the accumulation of ergothioneine is an adaptive mechanism to minimise oxidative damage (55)

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Specifically, NRF2 is significantly overexpressed in ESC tissues compared to other endometrial tumors and benign tissues, indicating a direct correlation between NRF2 levels and cancer aggressiveness (107) High NRF2 levels in these cancers also confer increased resistance of SPEC-2 cells to chemotherapy drugs like cisplatin and paclitaxel (107)