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Impaired individuals exhibit hypomethylation of CpG sites in the CCL11 promoter region, which are then hypermethylated upon supplementation with B12 In impaired individuals, three CpG sites exhibited hypomethylation when compared to the non-impaired group

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→ Fatigue or headaches → Rare but can occur in individuals sensitive to peptides affecting metabolic pathways

12 deficiency associated with inadequate vitamin B