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63 The accumulated NAPQI depletes GSH in the endoplasmic reticulum to induce an oxidation–reduction imbalance, which initiates the phosphorylation of eukaryotic initiation factor 2α (eIF2α) to activate ATF6 and CHOP, eventually resulting in hepatocyte apoptosis (Figure 2)

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Beyond that, they were developed for different purposes, have different research histories, and tend to show up in different types of products