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Who Should Not Undergo This Procedure Based on current clinical understanding, IV glutathione infusions are generally not appropriate for: Individuals who are pregnant or breastfeeding Patients with a history of kidney or liver disease Those with a known allergy to glutathione, ascorbic acid (Vitamin C), or any other component of the infusion Individuals with certain autoimmune or haematological conditions — these should be assessed and discussed with a doctor Comparing IV Glutathione to Evidence-Based Skin-Brightening Treatments For patients with concerns about skin tone, hyperpigmentation, melasma, post-inflammatory hyperpigmentation (PIH), or solar lentigines, a range of treatments with a more established evidence base are available in Singapore