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Despite heterogeneity and modest sample sizes, these findings establish a functional association between nutrient availability, MTHFR-dependent SAM synthesis and epigenetic control, underscoring the rationale for larger, mechanistically informed intervention studies (106,164,165)

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As shown in Figure 4, the relative gene expression levels of CAT, SOD, heme oxygenase 1 (HO‐1), transcription factor NF‐E2‐related factor 2 (Nrf2), and NAD(P)H quinone dehydrogenase 1 (NQO1) in HFDM‐L and HFDP‐L rats were markedly increased by a higher dose legume diet compared with the HFD group