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Experimental evidence showed that the lipid peroxidation product 4-HNE, at 0, 5, 10, 20, 30, and 50 µM, induces a dose-dependent decrease in meiotic competence during in vitro oocyte maturation, as well as aneuploidies in germinal vesicle (GV) oocytes from 20 µM of 4-HNE (Mihalas et al