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Through the so-called “lactate shuttle” mechanism, lactate is transported to neurons via monocarboxylate transporters (MCT4), providing metabolic fuel to neurons, presenting an “inverse Warburg effect.” However, impaired lactate oxidation in neurons leads to inefficient utilization, resulting in intracellular lactate accumulation, insufficient ATP synthesis, and a consequent drop in intracellular pH (acidosis) that further inhibits mitochondrial function [7, 112]

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Waves of adipose tissue growth in the genetically obese Zucker fatty rat

Production within the body declines with age