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Guideline-based “bacterial” patterns include: - Persistent symptoms that do not improve for about 10 days or longer - “Double-worsening” (you start to improve, then symptoms worsen again) - Severe symptoms (such as significant fever with purulent discharge and facial pain) For a deeper comparison, see: Red flags—seek urgent medical care - Eye swelling or vision changes - Severe headache, stiff neck, confusion - High fever, significant facial swelling - Immune compromise or serious underlying illness • If symptoms are protracted, severe, or worsening—especially with red flags—seek prompt evaluation

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- All existing clinical evidence for FOX04-DRI comes from preclinical (animal) studies