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Figure 3 5.2 Ferroptosis regulates RA synovial inflammation Synovial inflammation is a central event in the pathogenesis of RA, as well as a major trigger for bone and cartilage destruction and vascular opacification formation

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In the hypothalamus, LepRb is expressed in a subset of neurons in nuclei that are important for metabolic regulation, such as the arcuate nucleus (ARC), ventromedial nucleus of the hypothalamus (VMH) and dorsomedial nucleus of the hypothalamus, and in the lateral hypothalamic area 27 (FIG