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The satiety effect is additive with GLP-1 agonism because the pathways don't overlap — which is why CagriSema outperforms semaglutide monotherapy and tirzepatide on some endpoints

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Wohlgemuth, William K.|Factor, Stewart A.|Wittine, Lara|Amara, Amy W.|Wallace, Douglas M.|Malaty, Irene A.|Trotti, Lynn Marie|Hauser, Robert A.|Nallu, Sagarika Practical Evaluation and Management of Insomnia in Parkinson's Disease: A Review Movement Disorders Clinical Practice [23301619]