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One of the possible mechanisms of cytokine production involved in the pathogenesis of COPD is dependent on caspase 1 and the formation of the P3 inflammasome of the nucleotide-binding oligomerization domain (NLR) ( The oxidative load is also increased in COPD

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18 shows distributions of Spike sequence physicochemical weighted Hamming distances (scaled as numbers of mutations) and RBD antigenic escape distances to the Ancestral mRNA-1273 vaccine strain of the SARS-CoV-2 sequences estimated to be circulating in the CoVPN 3008 correlates study compared to those in the COVE and COVAIL correlates studies