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184 Indeed, several growth factors such as epithelial growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) can induce signaling pathways involving effector kinases downstream in the signaling cascade, including JAK/STAT3, MAPK, phosphatidylinositol-3 kinase (PI3K)/AKT/mTOR, and phospholipase C γ/protein kinase C (PLCγ/PKC)
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