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Given our previous data suggesting increased oxidative damage markers in the CNS following chronic consumption of HFDs (Langley et al., 2019, Yoon et al., 2016) and the relevance of oxidative stress in glia of MS lesions (Haider, Fischer et al., 2011, Lassmann & van Horssen, 2016, Miller, Dziedzic et al., 2019), we next sought to compare the extent of oxidative damage in the spinal cords of wildtype and CD38ci mice fed regular or HFD