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Therefore, the fact that vB12 treatment of Tbx1 +/− mice restored glutamate and inosine to WT levels is consistent with their metabolic relatedness and their dependence upon mitochondrial activity, which is responsive to vB12

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Several conditions interfere with the gut’s ability to absorb cobalamin effectively: Inflammatory bowel disease: Chronic inflammation of the small intestinal lining damages the cells responsible for absorbing nutrients, including B12