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Whether the isolated 17-to-23 fragment retains the ILK/AKT activity of the full protein is not fully established in peer-reviewed literature

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Previously, it was discussed that cuprizone may not be selective only for copper but can also chelate other heavy metals such as zinc, iron, and manganese and thus, impairs functions of additional important enzymes such as cytosolic zinc containing enzyme, anhydrase II (CA II) (Hoppel and Tandler, 1973)