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Data on inverse studies in advanced CKD and dialysis patients were reported, which led to the discovery of a potential phenomenon known as “reverse epidemiology.” Additional CVD risk factors associated with this phenomenon include blood pressure, plasma cholesterol levels, and body mass index [82]

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The mechanistic framework is grounded in published molecular biology, but human clinical evidence for 5-Amino-1MQ and MOTS-c specifically remains limited to early-phase or preclinical data, meaning the claimed synergy between all three compounds has not been tested as a combination in any published human trial

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