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In the guinea pig, renal activity of microsomal N -acetyltransferase is lower than that in mouse and rat kidney, whereas activity of the deacylase is higher (Lau et al., 1995)

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PD studies have shown a decline in kynurenic acid levels with elevation in 3-hydroxykynurenine levels favoring neurotoxic states in the frontal cortex, putamen and substantia nigra pars compacta brain regions (75, 77)