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These data suggest that the increase in oxidative stress and the parasite growth delay are a consequence of reduced GSH levels as is the case for the pbggcs-ko parasites

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Increases in AA and PUFAs in the brain lead to increases in water and sodium and decreases in potassium and the ATP-dependent Na+/K+ pump, leading to cerebral edema ( Vasogenic edema is a disruption of the BBB that results in extravasation of fluid and intravascular proteins (such as albumin) into the brain parenchyma