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While the role and mechanism of gene regulation via DNA methylation was well understood, the gene-specific methods described above helped bring these ideas to the context of complex diseases states, especially tumorigenesis (Jones and Laird, Comparative Methylation Profiling Using Microarray Technology Throughout the 1990s, the development of DNA microarray technology was responsible for a revolution in functional genomics, paving the way for high-throughput analysis of single nucleotide polymorphisms and other genomic variants (Southern et al., 1999)