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The activity of superoxide dismutase (SOD) in the tissue homogenate was assessed by measuring its ability to inhibit the autoxidation of epinephrine at pH 10.2 and 30°C [26]

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The role of V-ATPases in the control of vacuolar pH influences the pharmacokinetics of chemotherapeutic drugs and may be involved in multidrug resistance mechanisms and the metastatic potential of tumour cells [143–146]