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In this experiment, curcuminoid analogs FLDP-5 and FLDP-8 were used, and it showed that these two curcuminoid analogs were predicted to be BBB permeable (Ref

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Clonal expansion of mtDNA mutations denotes the process by which a particular mtDNA mutation, initially confined to a limited number of mitochondrial genomes, progressively becomes predominant within a cell or tissue over time