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To explore this hypothesis, we tested mitragynine ( 1 ), 7-hydroxymitragynine ( 2 ) and speciofoline ( 3 ) for µ-opioid receptor inhibition of forskolin-stimulated cyclic-AMP (cAMP) accumulation and for their ability to recruit β-arrestin-2 in CHO-K1 cells stably expressing the µ-opioid receptor

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This drug may transiently decrease the glomerular filtration rate (GFR) due to an afferent arteriolar constriction[25]