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NADP-dependent isocitrate dehydrogenase is a key enzyme of the Krebs cycle which produces NADP by oxidative decarboxylation of isocitrate to α-keto-glutarate

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In nucleotide metabolism, nucleobases and nucleosides such as uracil and uridine were markedly elevated by approximately 2-fold and 3.4-fold, respectively, reflecting active nucleic acid synthesis