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10.1111/mmi.12140 293 TilneyL
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[146] demonstrated that ARQ 761, an analogue of β-lapachone, administered intravenously in a stepped dose schedule, is activated in tumors with overexpression of the NQO1 enzyme, generating ROS overproduction and programmed necrotic cell death in a phase I trial involving patients with refractory advanced/metastatic solid tumors
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