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While the skin contains endogenous antioxidant defences, vitamins E and C and antioxidant enzymes to quench these oxidants and repair the resultant damage, these antioxidants will be consumed by repeated exposure and the skin’s defences can thereby be overwhelmed [25,138,139,140,141]

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Another study from UC Irvine recently validated that indeed GSH depletion precedes plaque deposition in transgenic AD mice [2]