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A.NADPH provides reductive power to maintain the function of antioxidant pathways including TRX and GSH systems NADPH is a crucial product of the immune metabolic pentose phosphate pathway (PPP) and has been shown to maintain redox homeostasis in immune cells while reducing ROS production

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STRENGTH:Core

Glutathione is a tri-peptide (L-g-glutamyl-L-cysteinyl-glycine) that acts as both reducing agent and capping agent, which assemble on the surface of AuNCs via a stable gold-thiol linkage (from cysteine) and imparts the nanoclusters with a net negative surface charge (zeta potential = −32 ± 4.2 mV, pH = 7.5) due to the presence of terminal carboxylic acid functional groups (sketch depicting the assembly of glutathione molecules on GSH-AuNCs and the chemical structure of glutathione peptide is shown in Fig