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Monitoring Protocol: Although the trials showed no concerning laboratory changes, prudent clinical practice suggests baseline and periodic monitoring of metabolic parameters, complete blood counts, liver function, and kidney function

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Selectivity of NNMT inhibitors Test compounds were screened in biochemical assays for activity against three structurally similar methyltransferases, including catechol-O-methyltransferase (COMT), DNA (cytosine-5)-methyltransferase 1 (DNMT1), and protein arginine methyltransferase 3 (PRMT3)