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The PKC pathway becomes activated through hyperglycemia-induced increases in diacylglycerol (DAG), with PKC-β and PKC-δ isoforms particularly implicated in stimulating NOX activity while inhibiting AMPK-mediated antioxidant responses (Geraldes and King, 2018)

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doi: 10.1016/j.jad.2022.10.001 [DOI] [PubMed] [Google Scholar] 26.Sonali S, Ray B, Ahmed Tousif H, et al