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Dermal edema and erythrocyte extravasation may be present, as well as spongiosis, a pseudolymphomatous reaction, and focal epidermal necrosis.43,44 Laboratory alterations Eosinophilia, in varying degrees, is one of the characteristics of the syndrome, is present in up to 95.5% of cases at some stage of the disease and may persist after the normalization of liver enzymes.32,45 Several cytokines are involved in the activation and recruitment of eosinophils
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Subsequently, according to the method described in the previous study ( 2.7 Immunofluorescence (IF) After transcardial perfusion in mice, brain tissues were harvested and pretreated with gradient dehydration in 20% and 30% sucrose solutions at 4°C (to reduce ice crystal damage), then embedded in optimal cutting temperature compound and sectioned for 20 μm thickness using cryostat
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