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At the same time, ferroptosis causes ferritin degradation, affects iron metabolism and leads to iron overload ( Related Diseases and Mechanism of Iron Overload When there is too much iron in the body, the body will mount a defensive response, but after excess iron exceeds the binding capacity of serum FPN, it becomes labile plasma iron (LPI), labile cellular iron (LCI), or non-transferrin bound iron (NTBI)