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To the best of our knowledge, this is the first study to show that HCQS negatively affects fracture healing by causing lipid peroxidation and changes in the antioxidant defense system.[17] Another important result of the study is that although ALP level, callus formation, callus\diaphysis ratio, and BMD values were lower in Group 2 given dose-equivalent HCQS at three and six weeks, there was no statistically significant difference in Group 3 at both three and six weeks