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A history of pain hypersensitivity in the affected region of pain and defined comorbidities strengthen the probability of nociplastic pain, and both must be present to designate probable nociplastic pain” ( With an estimated prevalence ranging from 5% to 15% of the general population, NPP mainly manifests as distinct neurological symptoms in local or multiple regions of the body ( Sensitization, particularly central sensitization, may serve as a common mechanistic link between the pathogenesis of NPP and that of NP and/or) NCP

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doi: 10.1007/s00894-023-05457-z

which is a special blend of glutathione and essential phospholipids