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This can significantly increase the efficacy of anti-cancer therapies, as a well-normalized vasculature allows for better perfusion and more efficient distribution of drugs ( Moreover, other signaling pathways, such as those involving HIFs and MMPs, also play significant roles in regulating the angiogenic process, especially under hypoxic conditions ( 3.2 Clinical applications of vascular disruption drugs The clinical application of vascular disruption drugs, particularly anti-VEGF agents, has revolutionized the treatment landscape for various malignancies