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Chaperone protein copper chaperone for superoxide dismutase (CCS) facilitates the transport of copper ions to superoxide dismutase 1 (SOD1) (28), and ATOX1 plays a crucial role in transporting copper ions to the nucleus for binding with transcription factors to regulate gene expression while also transferring them from the trans-Golgi network (TGN) to ATPase α-peptide (ATP7A) and ATPase β-peptide (ATP7B) (30)